The room matters as much as the molecule
"Set and setting" is often treated as a slogan. In clinical practice it is closer to the active ingredient — and treating it casually is where harm tends to begin.
The lead essay
Psychedelic trials report dramatic numbers. Understanding what those numbers measure — and what they quietly leave out — is the first step to reading them honestly.
Latest essays
"Set and setting" is often treated as a slogan. In clinical practice it is closer to the active ingredient — and treating it casually is where harm tends to begin.
The dramatic part is over in a day. Whether anything changes depends on the unglamorous weeks that follow — and on having somewhere to bring what surfaced.
The clinical label describes what medicines have failed to do, not what a person is. That distinction changes how we read the research — and how we treat the people in it.
Trauma is not only a memory problem. Understanding why it lives in the body helps explain why some emerging therapies work on the body's terms, not the mind's alone.
If psychedelic therapy becomes a real treatment, the next question is not whether it works but who will be able to reach it — and whether access will follow need or money.
Practical guides
A calm, practical guide to raising the subject with a clinician — what to ask, what to expect, and how to tell credible care from a sales pitch.
The two oldest words in this field, explained without mysticism — what they actually refer to, why clinicians take them so seriously, and how to apply the idea.
A harm-reduction guide for friends and family — how to be useful to someone shaken by a psychedelic experience, and how to recognise when to seek help.
The newsletter
New essays and guides, plus a short, honest note on what the evidence does and doesn’t yet show.